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Author Topic: Bisphenol A  (Read 1613 times)

tipsy toaster

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Bisphenol A
« on: July 18, 2010, 06:30:55 PM »

vorab: es fehlt eine passende Kategorie fürs Thema schädliche Chemikalien in der Umwelt (oder so ähnlich).

Für einen ansatzweisen Überblick hier die bisherigen Postings zu Bisphenol A:
http://transgallaxys.com/~kanzlerzwo/index.php?topic=4537.msg10034;topicseen#msg10034
http://transgallaxys.com/~kanzlerzwo/index.php?topic=6348.msg14408;topicseen#msg14408
http://transgallaxys.com/~kanzlerzwo/index.php?topic=6314.msg14344;topicseen#msg14344



NEU: Pressemeldung der EFSA (European Food Safety Agency) vom 13.7.2010
http://www.efsa.europa.eu/de/press/news/cef20100713.htm

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EFSA analysiert mehr als 800 Studien über BPA, um Gutachten in diesem September abschließen zu können
Webnachricht
13 Juli 2010

aktualisiert

Wissenschaftler des CEF-Gremiums der Europäischen Behörde für Lebensmittelsicherheit arbeiten an einem umfassenden Gutachten über Bisphenol A (BPA), welches eine Bewertung der Studie zur Untersuchung der Neuroentwicklungstoxizität von BPA bei Ratten (Stump 2009), der Empfehlungen des Lebensmittelinstitutes der Dänischen Technischen Universität (DTU) bezüglich der Risikobewertung von BPA, einen umfassenden Überblick über die Literatur zur Toxizität von BPA sowie Gesamtschlussfolgerungen beinhaltet.

BPA wird bei der Herstellung von Polycarbonatkunststoffen — einschließlich Materialien, die mit Lebensmitteln in Berührung kommen, wie zum Beispiel Säuglingsfläschchen und Innenbeschichtungen von Konservendosen — vielfach verwendet und ist mit einer Reihe von Gesundheitsproblemen in Zusammenhang gebracht worden.

Für den Überblick über die wissenschaftliche Literatur berücksichtigte das Gremium über 800 Veröffentlichungen, deren Analyse erheblich mehr Zeit als geplant erforderte. Auf seiner Plenarsitzung am 6.-8. Juli dieses Jahres verbrachte das Gremium den größten Teil der Zeit damit, die Ergebnisse dieser Studien zu erörtern, und es blieb zu wenig Zeit, um das Gutachten ganz fertigzustellen und anzunehmen.

In einem Schreiben an die Europäische Kommission hat die EFSA daraufhingewiesen, dass sich das Gremium in seinen bisherigen Beratungen für die Beibehaltung der tolerierbaren täglichen Aufnahmemenge (TDI) für BPA von 0,05 mg/kg KG pro Tag ausspricht, wobei jedoch der Vorschlag unterbreitet wurde, den TDI-Wert in einen vorläufigen TDI-Wert umzuwandeln. Gleichzeitig identifizierte das Gremium Unsicherheitsbereiche, die genauer untersucht werden sollten.

Das Gremium berücksichtigte auch die Studie von Stump (2009), auf deren wissenschaftlicher Grundlage Dänemark die Verwendung von BPA in Materialien verboten hat, die mit Lebensmitteln für Kinder im Alter von 0-3 Jahren in Berührung kommen. Das Gremium gelangte zu dem Ergebnis, dass die Studie keine Belege für einen Einfluss von BPA auf die neurologischen Endpunkte des Studiendesigns liefert und deshalb das Gremium nicht dazu veranlasst, eine Änderung des TDI-Wertes für BPA in Betracht zu ziehen. Das Gremium hat in seinen bisherigen Erörterungen die in der Risikobewertung des dänischen DTU-Lebensmittelinstituts beschriebenen möglichen Auswirkungen von niedrigen Dosen auf die Lernfähigkeit ausgeschlossen.

Die Mitglieder des CEF-Gremiums werden den Sommer hindurch in Telekonferenzen weiter an dem Gutachten arbeiten, um es vollständig fertigzustellen und auf einer außerordentlichen Plenarsitzung im September zu verabschieden.

Die EFSA hat in den vergangenen Monaten Konsultationen mit nationalen Sachverständigen aus ganz Europa sowie mit verschiedenen internationalen Risikobewertungsgremien zum Thema Bisphenol A abgehalten, wobei u. a. auch Fragen des Designs von wissenschaftlichen Studien über BPA, toxikologische Gesichtspunkte und die Stärken und Schwächen einzelner Studien diskutiert wurden.

Ähnliche Fragestellungen — sowie Einzelheiten zu neuen Risikobewertungen und auf der ganzen Welt durchgeführten Studien — wurden auch mit der Food and Drug Administration (FDA) der USA, Health Canada, Food Standards Australia New Zealand (FSANZ), der Lebensmittelsicherheitskommission von Japan und der Weltgesundheitsorganisation (WHO) erörtert.


Für Medienanfragen wenden Sie sich bitte an:
Steve Pagani, Leiter des Pressedienstes
Tel.: +39 0521 036149
E-Mail: press@efsa.europa.eu

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mehr Info:
http://www.efsa.europa.eu/de/ceftopics/topic/bisphenol.htm?wtrl=01
dort auch wissenschaftliche Dokumente und Pressemitteilungen zum Thema

FAQ und Antworten zu Bisphenol A:
http://www.efsa.europa.eu/de/faqs/faqbisphenol.htm

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tipsy toaster

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Re: Bisphenol A
« Reply #1 on: August 05, 2010, 03:54:16 PM »

Bisphenol A schädigt Spermien

http://www.aerzteblatt.de/nachrichten/42231/Bisphenol_A_schaedigt_Spermien.htm

Abstract der Studie:
http://www.ncbi.nlm.nih.gov/pubmed/20656017

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Reprod Toxicol. 2010 Jul 23. [Epub ahead of print]
Semen quality and sperm DNA damage in relation to urinary bisphenol A among men from an infertility clinic.

Meeker JD, Ehrlich S, Toth TL, Wright DL, Calafat AM, Trisini AT, Ye X, Hauser R.

Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI, United States.
Abstract

Bisphenol A (BPA) impairs spermatogenesis in animals, but human studies are lacking. We measured urinary BPA concentrations, semen quality, and sperm DNA damage (comet assay) in 190 men recruited through an infertility clinic. BPA was detected in 89% of samples, with a median (interquartile range [IQR]) concentration of 1.3 (0.8-2.5) ng/mL. Urinary BPA concentration was associated with slightly elevated, though not statistically significant, odds for below reference sperm concentration, motility, and morphology. When modeled as continuous dependent variables, an IQR increase in urinary BPA concentration was associated with declines in sperm concentration, motility, and morphology of 23% (95%CI -40%, -0.3%), 7.5% (-17%, +1.5%), and 13% (-26%, -0.1%), respectively, along with a 10% (0.03%, 19%) increase in sperm DNA damage measured as the percentage of DNA in comet tail. In conclusion, urinary BPA may be associated with declined semen quality and increased sperm DNA damage, but confirmatory studies are needed. Copyright © 2010. Published by Elsevier Inc.

PMID: 20656017
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Weitere Studie aus China:
Relationship between Urine Bisphenol-1 A (BPA) Level and Declining Male Sexual
Function

Volltext der Studie als pdf:
http://www.andrologyjournal.org/cgi/rapidpdf/jandrol.110.010413v1.pdf


Aktuelle FDA-Publikation zum Thema:
Update on Bisphenol A for Use in Food Contact Applications: January 2010
http://www.fda.gov/NewsEvents/PublicHealthFocus/ucm197739.htm



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« Last Edit: November 26, 2011, 11:55:36 AM by ama »
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tipsy toaster

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Re: Bisphenol A
« Reply #2 on: November 08, 2010, 05:05:18 PM »

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Montag, 8. November 2010
Medizin Bisphenol A geht durch die Haut

Toulouse/Boston – Das Thermopapier, mit dem viele Kassenbelege gedruckt werden, ist mit der Chemikalie Bisphenol A (BPA) belastet. Es wird über die Haut aufgenommen, was die hohe Exposition bei Supermarktkassiererinnen erklärt.

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mehr:
http://www.aerzteblatt.de/nachrichten/43404/Bisphenol_A_geht_durch_die_Haut.htm


Abstract der Studien:

http://www.ncbi.nlm.nih.gov/pubmed/21030062
Chemosphere. 2010 Oct 26. [Epub ahead of print]
Viable skin efficiently absorbs and metabolizes bisphenol A.
Zalko D, Jacques C, Duplan H, Bruel S, Perdu E.

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INRA, UMR1089 Xénobiotiques, 180 Chemin de Tournefeuille, BP 93173, 31027 Toulouse Cedex 3, France.

Abstract

Skin contact has been hypothesized to contribute to human exposure to bisphenol A (BPA). We examined the diffusion and metabolism of BPA using viable skin models: human skin explants and short-term cultures of pig ear skin, an alternative model for the study of the fate of xenobiotics following contact exposure. (14)C-BPA [50-800nmol] was applied on the surface of skin models. Radioactivity distribution was measured in all skin compartments and in the diffusion cells of static cells diffusion systems. BPA and metabolites were further quantified by radio-HPLC. BPA was efficiently absorbed in short-term cultures, with no major difference between the models used in the study [viable pig ear skin: 65%; viable human explants: 46%; non-viable (previously frozen) pig skin: 58%]. BPA was extensively metabolized in viable systems only. Major BPA metabolites produced by the skin were BPA mono-glucuronide and BPA mono-sulfate, accounting together for 73% and 27% of the dose, in pig and human, respectively. In conclusion, experiments with viable skin models unequivocally demonstrate that BPA is readily absorbed and metabolized by the skin. The trans-dermal route is expected to contribute substantially to BPA exposure in human, when direct contact with BPA (free monomer) occurs.
Copyright © 2010. Published by Elsevier Ltd.
PMID: 21030062
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http://ehp03.niehs.nih.gov/article/info%3Adoi%2F10.1289%2Fehp.1002366

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Research Article
Variability and Predictors of Urinary Bisphenol A Concentrations during Pregnancy

    * Article

Formal Correction: This article has been formally corrected to address the following errors.

Jump to

Joe M. Braun, Amy E. Kalkbrenner, Antonia M. Calafat, John T. Bernert, Xiaoyun Ye, Manori J. Silva, Dana Boyd Barr, Sheela Sathyanarayana, Bruce P. Lanphear

Abstract Top

Background: Prenatal bisphenol A (BPA) exposure may be associated with developmental toxicity, but few studies have examined the variability and predictors of urinary BPA concentrations during pregnancy.

Objective: To estimate the variability and predictors of serial urinary BPA concentrations taken during pregnancy.

Methods: We measured BPA concentrations during pregnancy and at birth in three spot urine samples from 389 women. We calculated the intraclass correlation coefficient (ICC) to assess BPA variability and estimated associations between log10-transformed urinary BPA concentrations and demographic, occupational, dietary, and environmental factors using mixed models.

Results: Geometric mean (GM) creatinine-standardized concentrations (μg/g) were 1.7 (16 weeks), 2.0 (26 weeks), and 2.0 (birth). Creatinine-standardized BPA concentrations exhibited low reproducibility (ICC: 0.11). By occupation, cashiers had the highest BPA concentrations (GM: 2.8 μg/g). Consuming canned vegetables at least once a day was associated with higher BPA concentrations (GM: 2.3 μg/g) compared to those consuming no canned vegetables (GM: 1.6 μg/g). BPA concentrations did not vary by consumption of fresh fruits and vegetables, canned fruit, or store-bough fresh and frozen fish. Urinary high molecular weight phthalate and serum tobacco smoke metabolite concentrations were positively associated with BPA concentrations.

Conclusions: These results suggest that numerous sources of BPA exposure during pregnancy exist. Etiological studies may need to measure urinary BPA concentrations more than once during pregnancy and adjust for phthalates and tobacco smoke exposures.

Citation: Braun JM, Kalkbrenner AE, Calafat AM, Bernert JT, Ye X, Silva MJ, et al. 2010. Variability and Predictors of Urinary Bisphenol A Concentrations during Pregnancy. Environ Health Perspect :-. doi:10.1289/ehp.1002366
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« Last Edit: November 26, 2011, 11:54:45 AM by ama »
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tipsy toaster

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Re: Bisphenol A
« Reply #3 on: November 28, 2010, 03:13:25 PM »

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tipsy toaster

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Re: Bisphenol A
« Reply #4 on: February 11, 2011, 07:21:39 PM »

.
SpOn 11.2.2011:

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Regierung verbietet Bisphenol A in Babyflaschen

Babyflaschen mit der umstrittenen Chemikalie Bisphenol A dürfen in Deutschland nicht mehr hergestellt werden. Für bereits hergestellte Ware gilt eine Übergangsfrist, erst ab Juni werden sie ganz aus den Verkaufsregalen verbannt. Forscher warnen, dass die Substanz die Hirnentwicklung stört.
...
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Volltext:
http://www.spiegel.de/wissenschaft/mensch/0,1518,745019,00.html


auch im Ärzteblatt:

Bisphenol A in Babyfläschchen ab März verboten
http://www.aerzteblatt.de/nachrichten/44668/Bisphenol_A_in_Babyflaeschchen_ab_Maerz_verboten.htm
.
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ama

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Dosennahrung: Gravierende Mengen von Bisphenol A im Blut nachgewiesen!
« Reply #5 on: November 26, 2011, 11:44:58 AM »

http://www.hsph.harvard.edu/news/press-releases/2011-releases/canned-soup-bpa.html

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Press Releases
2011 Releases

Consuming Canned Soup Linked to Greatly Elevated Levels of the Chemical BPA
 
BPA, Found in Soup Can Lining, Associated with Adverse Health Effects in Humans

For immediate release: Tuesday, November 22, 2011

A new study from researchers at the Harvard School of Public Health (HSPH) has found that a group of volunteers who consumed a serving of canned soup each day for five days had a more than 1,000% increase in urinary bisphenol A (BPA) concentrations compared with when the same individuals consumed fresh soup daily for five days. The study is one of the first to quantify BPA levels in humans after ingestion of canned foods.

The findings were published online November 22, 2011, in the Journal of the American Medical Association (JAMA) and will appear in the November 23/30 print issue.

“Previous studies have linked elevated BPA levels with adverse health effects. The next step was to figure out how people are getting exposed to BPA. We’ve known for a while that drinking beverages that have been stored in certain hard plastics can increase the amount of BPA in your body. This study suggests that canned foods may be an even greater concern, especially given their wide use,” said Jenny Carwile, a doctoral student in the Department of Epidemiology at HSPH and lead author of the study.

Exposure to the endocrine-disrupting chemical BPA, used in the lining of metal food and beverage cans, has been shown to interfere with reproductive development in animals and has been linked with cardiovascular disease, diabetes, and obesity in humans. In addition to the lining of food and beverage cans, BPA is also found in polycarbonate bottles (identified by the recycling number 7) and dentistry composites and sealants.

The researchers, led by Carwile and Karin Michels, associate professor in the Department of Epidemiology, set out to quantify whether canned-soup consumption would increase urinary BPA concentrations relative to eating fresh soup.

They recruited student and staff volunteers from HSPH. One group consumed a 12-ounce serving of vegetarian canned soup each day for five days; another group consumed 12 ounces of vegetarian fresh soup (prepared without canned ingredients) daily for five days. After a two-day “washout” period, the groups reversed their assignments.

Urine samples of the 75 volunteers taken during the testing showed that consumption of a serving of canned soup daily was associated with a 1,221% increase in BPA compared to levels in urine collected after consumption of fresh soup.

The researchers note that the elevation in urinary BPA concentrations may be temporary and that further research is needed to quantify its duration.

“The magnitude of the rise in urinary BPA we observed after just one serving of soup was unexpected and may be of concern among individuals who regularly consume foods from cans or drink several canned beverages daily. It may be advisable for manufacturers to consider eliminating BPA from can linings,” said Michels, senior author of the study.

Support for this study was provided by an Allen Foundation grant and a Training Grant in Environmental Epidemiology from the National Institute of Environmental Health Sciences.

“Canned Soup Consumption and Urinary Bishphenol A: A Randomized Crossover Trial,” Jenny L. Carwile, Xiaoyun Ye, Xiaoliu Zhou, Anotonia M. Calafat, Karin B. Michels, JAMA, online Nov. 22, 2011; in Nov. 23/30 print issue.

For more information:

Todd Datz
617-432-8413
tdatz[bat]hsph.harvard.edu


Visit the HSPH website for the latest news, press releases and multimedia offerings.

###

Harvard School of Public Health is dedicated to advancing the public’s health through learning, discovery and communication. More than 400 faculty members are engaged in teaching and training the 1,000-plus student body in a broad spectrum of disciplines crucial to the health and well being of individuals and populations around the world. Programs and projects range from the molecular biology of AIDS vaccines to the epidemiology of cancer; from risk analysis to violence prevention; from maternal and children’s health to quality of care measurement; from health care management to international health and human rights. For more information on the school visit www.hsph.harvard.edu.

HSPH on Twitter: http://twitter.com/HarvardHSPH
HSPH on Facebook: http://www.facebook.com/harvardpublichealth
HSPH on You Tube: http://www.youtube.com/user/HarvardPublicHealth
HSPH home page: http://www.hsph.harvard.edu
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