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Author Topic: Isolation Krebs erregender Stammzellen gelungen  (Read 1239 times)


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Isolation Krebs erregender Stammzellen gelungen
« on: June 25, 2007, 07:08:48 PM »

Der "Standard" hat eine gute Wissenschafts-Abteilung:


derStandard.at | Wissenschaft | Mensch
25.06.2007 10:00

Isolation Krebs erregender Stammzellen gelungen

Als nächster Schritt müssen die als Rezeptoren dienenden Proteine ermittelt werden

Mailand - Im Rahmen einer Versuchsreihe des zum Nationalen Forschungsrat
CNR gehörenden Istituto di Tecnologie Biomedicali ist die Isolation Krebs
erregender Stammzellen (cancer stem cells) gelungen, die wegen ihrer hohen
Resistenz auch nach einer chemischen oder operativen Behandlung für ein
Wiederaufleben und Fortschreiten der Erkrankung verantwortlich sind.

Pnas: The properties of a mammary gland cancer stem cell

©derStandard.at 2007

Der Abstract im Original:

Published online before print June 12, 2007, 10.1073/pnas.0703071104

PNAS | June 19, 2007 | vol. 104 | no. 25 | 10476-10481

The properties of a mammary gland cancer stem cell

I. Zucchi*,, S. Sanzone*, S. Astigiano, P. Pelucchi*, M. Scotti*,
V. Valsecchi*, O. Barbieri,, G. Bertoli*, A. Albertini*, R. A. Reinbold¶,
and R. Dulbecco,

*Institute of Biomedical Technologies, National Research Council, Via
Cervi 93, 20090 Segrate-Milan, Italy; Istituto Scientifico per lo Studio e
la Cura dei Tumori, Largo Benzi 10, 16132 Genoa, Italy; Dipartimento di
Medicina Sperimentale, Università di Genova, Largo Benzi 10, 16132 Genoa,
Italy; ¶Max Planck Institute, D48149 Muenster, Germany; and ||The Salk
Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037

Contributed by R. Dulbecco, April 5, 2007 (received for review March 1,

The cancer stem cell hypothesis posits that tumors are derived from a
single cancer-initiating cell with stem cell properties. The task of
identifying and characterizing a single cancer-initiating cell with stem
cell properties has proven technically difficult because of the scarcity
of the cancer stem cells in the tissue of origin and the lack of specific
markers for cancer stem cells. Here we show that a single LA7 cell derived
from rat mammary adenocarcinoma has the following properties: the
differentiation potential to generate all of the cell lineages of the
mammary gland; the ability to generate branched duct-like structures that
recapitulate morphologically and functionally the ductal–alveolar-like
architecture of the mammary tree; and the capacity to initiate
heterogeneous tumors in nonobese diabetic-SCID mice. In addition, we show
that cultured cells derived from tumors generated by a single LA7
cell-injection have properties similar to LA7 cells, can generate all of
the cell lineages of the mammary gland, and recapitulate the
ductal–alveolar-like architecture of the mammary tree. The properties of
self-renewal, extensive capacity for proliferation, multilineage
differentiation potential, and single-cell tumor-initiation potential
suggest that LA7 cells are cancer stem cells and can be used as a model
system to study the dynamics of tumor formation at the single-cell level.

p21/WAF1 | mammary gland differentiation | single cell injection

Author contributions: I.Z., S.S., and S.A. contributed equally to this
work; I.Z., R.A.R., and R.D. designed research; I.Z., S.S., S.A., and P.P.
performed research; I.Z., S.A., M.S., V.V., O.B., G.B., A.A., and R.A.R.
contributed new reagents/analytic tools; I.Z., S.S., S.A., R.A.R., and
R.D. analyzed data; and I.Z., R.A.R., and R.D. wrote the paper.

The authors declare no conflict of interest.

To whom correspondence may be addressed. E-mail: ileana.zucchi{at}itb.cnr.it
or rdulbeccomd{at}sbcglobal.net

© 2007 by The National Academy of Sciences of the USA

Copyright © 2007 by the National Academy of Sciences

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